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These peptides inhibit the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing vascular resistance and blood pressure (Ebner et al., 2015)

Environ Health Perspect.116(9):1154-61

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Thus, the ATP depletion and mitochondrial ROS burst observed upon SLC25A39 knockdown are expected to blunt PI3K/AKT signaling and subsequently inhibit mTORC1, driving the observed cell death