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Although present in neurons during development(Bernstein et al., 1987), in the mature brain the enzyme is found on the ependymal cells of the blood-brain barrier(Bernstein et al., 1987), and low concentrations of the soluble form of the enzyme can be found in the cerebrospinal fluid(Kato et al., 1979)

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Overdose of B12 can cause anxiety, acne, skin redness, headache, nausea, vomiting, heart stroke, face paralysis, palpitations, facial ruddiness, and insomnia

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