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[1] Retatrutide (trials): once-weekly subcutaneous administration, starting low (e.g., 2 mg) and escalating to 4, 8, or 12 mg maintenance, with slower titration used to improve tolerability

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Semaglutide's STEP 1 trial (1,961 subjects, 68 weeks) demonstrated 14.9% mean weight loss

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Examines NNMT regulation in hepatic tissue and its relationship to fasting states and lipid metabolism, providing mechanistic context for NNMT inhibitor research