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Everything below is framed for in vitro and animal-model research

In clinical trials of semaglutide injection for weight management, patients treated with semaglutide had a mean increase from baseline in amylase of 16% and lipase of 39%

However, in the 25 to 33% of patients who experience shunting with thiopurine monotherapy (preferential metabolism to less effective and potentially toxic thiopurine metabolites), low doses of thiopurines in combination with allopurinol may be prescribed to improve therapeutic effect