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A combination of automated and manual rebuilding and refinement in Refmac 29 and COOT 30 were used to produce the refined models

GLP-1 agonists also lower fat mass by curbing appetite and improving metabolic markers like insulin sensitivity and glucose control

The distance between the edges of the wound were measured at ten different areas from the wound edge to edge using Spot software

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The measurements were then converted into a percentage using the following formula: % of wound remaining = (measurement at time 12 hours/measurement at time 0 hours) 100