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This preparation is contraindicated in patients who are sensitive to cobalt and/or vitamin B12. As this product contains benzyl alcohol, it should not be used in newborns or in people who are sensitive to benzyl alcohol

The predicted binding mode places neuromedin C along the canonical peptide-binding groove, consistent with the class B1 GPCR two-domain recognition paradigm in which peptide ligands are initially oriented by extracellular receptor elements and subsequently stabilize the active TM architecture required for signaling (Figure 4)

While rodent studies showed thyroid C-cell tumors with GLP-1 medications, no clear human signal has emerged despite extensive use