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What the conversation covers Unique challenges in type 1 diabetes , why insulin alone has structural limitations The mechanism , how GLP-1 therapies work The evidence in type 1 diabetes , from early studies to ADJUST T1D and tirzepatide Exploration points , what the evidence tends to show on insulin adjustment, monitoring, and nutrition Future directions , triple and quadruple agonists, reimbursement, and paediatric potential Watch or listen Key themes Why insulin alone has structural limitations The episode opens by exploring why insulin alone has structural limitations in type 1 diabetes
Have struggled with repeated weight regain after diets or medications
FSHR and LHR are both G-protein coupled receptors (GPCRs) that transmit the intracellular cascade via adenylate cyclase activity, cAMP accumulation, with subsequent activation of PKA, which then phosphorylates the transcription factor CREB (cAMP response element binding protein)
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