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This alteration is closely associated with vasogenic edema and the disruption of the BBB (101)

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When the molar ratio of the coordinating functional groups remains constant, the absorbance observed at 584 nm for the dimer was larger than that of the monomer peptide, indicating that D-P possesses better coordination efficacy and greater stability than M-P (Fig

& Porcal, W

It is noteworthy that clinical studies have revealed an upregulation in the expression of STAT3 within the intestinal mucosa of individuals suffering from IBD (Zhao et al., 2021)