The SURPASS program established efficacy in type 2 diabetes across multiple comparators, including head-to-head superiority versus semaglutide on HbA1c reduction in SURPASS-2 (Fras et al., NEJM, 2021)
In an interview in 1976, Albert Hofmann, who discovered LSD, said small doses of psychedelics could improve mood and help with depression
Key approved indications include: Type 2 diabetes mellitus management (Mounjaro) Chronic weight management in obesity or overweight with comorbidities (Zepbound) Use as adjunct to lifestyle modification (diet and exercise) It is critical to recognize that tirzepatide has no FDA approval for the treatment, prevention, or management of autoimmune diseases
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Shortage of GLP-1 receptor agonists - National Patient Safety Alert, Kabahizi A et al (2022) Feb., Glucagon-like peptide-1 (GLP-1) signalling in the brain: From neural circuits and metabolism to therapeutics., Br J Pharmacol , vol
