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The acylation modification gives retatrutide a half-life of approximately six days, allowing once-weekly dosing, but that long half-life also means dosing errors compound over time rather than resolving quickly

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The objective of the study was to demonstrate that retatrutide is superior to placebo in WOMAC pain subscale score reduction and in body weight reduction from baseline to week 68 in people with a BMI 27.0 kg/m and who met American College of Rheumatology Criteria (clinical and radiological) for knee osteoarthritis

A 2024 study published in The Lancet reported that approximately 2539% of the weight lost through GLP-1 treatment is lean mass, not fat (Prado et al

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