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After consideration of the public comments we received and our review of the application, we have determined that the aprevo Cervical ACDF System meets the eligibility criterion at 419.66(b)(3)

Goat polio, properly known as polioencephalomalacia, is the most significant consequence of a thiamine deficiency

The following data were collected: publication year, country and continent, study setting (e.g., hospital, private practice, academic clinic), sample size, age range, mean age, study design, population characteristics, intervention details, outcomes, and effect measures (e.g., serum B12 levels)

Vitamin B-12 is a water-soluble vitamin that helps the brain work and makes red blood cells