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The logic behind combining these compounds comes down to addressing two separate problems simultaneously

doi: 10.1016/j.immuni.2019.04.011 95 KoutsakosMWheatleyAKLohLClemensEBSantSNussingSet al

Measurement: Interdisciplinary Research and Perspectives 22(2):17587 Beger RD, Goodacre R, Jones CM, Lippa KA, Mayboroda OA, ONeill D, Najdekr L, Ntai I, Wilson ID, Dunn WB (2024) Analysis types and quantification methods applied in UHPLC-MS metabolomics research: a tutorial

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For most people, particularly those of European ancestry, folic acid remains an effective way to support methylation and lower elevated homocysteine