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In addition, in vivo imaging demonstrated that PEG-PDA@rutin NPs effectively accumulate in the kidneys following I/R injury and ameliorate renal I/R injury

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In the present study, successive reserpine (1 mg/kg, SC) administration resulted in a significant increase in oxidative stress markers MDA, H 2 O 2 , and NO accompanied by a significant decrease in GSH 31,32

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