For example, analysis of four studies on suicidality in adults with bipolar disorder, major or bipolar depressive disorder or no mental illness found that liraglutide was not linked to significantly increased rates of suicidal ideation (having thoughts of suicide).Two further studies of exenatide in patients with alcohol use disorder and liraglutide in bipolar disorder found no significant difference in suicidal behaviour compared with placebo
Other antidiabetic drugs owing to the increased risk of hypoglycaemia, the dose of concomitant sulfonylurea and/or insulin may need to be reduced
Patients on GLP-1 medications may be losing muscle along with fat, potentially leading to frailty despite a lower weight
Neuropeptides 69 , 3945 (2018)
Researchers at the San Francisco Department of Public Health, however, are now conducting the first human clinical trial of a semaglutide a medication sold under the brand name Wegovy, among others, that reduces appetite by mimicking the action of the hormone GLP-1 as a way to treat addiction to methamphetamines
