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The compound activates the GIP receptor (glucose-dependent insulinotropic polypeptide), the GLP-1 receptor (glucagon-like peptide-1), and the glucagon receptor simultaneously [1]

9 Foods and Supplements That Increase GLP-1 Naturally Jocelyn McTavish Oct 1, 2025 8 min read Updated: Apr 21 Written by Nicole Rowe, MD | Reviewed by Katie E

368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption