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TMAVA also inhibits carnitine metabolism by simultaneously inhibiting carnitine synthesis and uptake in cardiac tissue, accelerating the development of cardiac hypertrophy [251]

In the early phases of neuroinflammation, gene expression tends to favor proliferation, whereas in later stages, immune-response genes become predominant, accompanied by the downregulation of homeostatic genes responsible for structural integrity, cell adhesion, and receptor function [31, 42, 43]

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This excess intake will exceed the capacity of the urea cycle, especially if it has an enzymatic deficit