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Female rats demonstrated equivocal evidence of carcinogenic activity based on increased incidences of mononuclear cell leukemia at 0.8 times the maximum human daily dose (MHDD) of 4 grams/day, based on a body surface area comparison

Lancet 2017;390:1664-75.ArticlePubMedPMC 83

KPV KPV engages the melanocortin system through MC1R and potentially MC3R, producing downstream suppression of pro-inflammatory cytokines (IL-1, IL-6, TNF-)

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