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Targeting mitochondria to restore exhausted T cell antitumor function By targeting T cell mitochondria metabolism, enhancing mitochondrial biogenesis, and improving mitochondrial structure and function to restore the energy supply and function of exhausted T cells, the strategies that have been applied up to date are as follows (Table 1)

doi: 10.1016/s1534-5807(03)00100-x 68 ScullCMTabasI

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