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SGLT2is provide cardio-renal benefits, despite an increase in the risk of DKA and urinary tract infection compared with GLP-1 RA therapy

The dosing schedule of retatrutide is as follows: Weeks 1-4: 1 mg or 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 8 mg once weekly Week 13+: 8 mg or 12 mg once weekly (Maintenance Dose) However, some trial arms tested higher doses (up to 8 mg or 12 mg as the final dose)

Produced using established synthetic peptide manufacturing methods, it is supplied as a white to off-white lyophilized powder consistent with the expected physicochemical characteristics of high-purity research peptides

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