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Oxidative stress also plays a role in sickle cell anemia, cystic fibrosis, and seizures

NLRP3 also influences macrophage polarization, ensuring timely transition from pro-inflammatory to pro-repair phenotypes

Thus, it can be that the general NO-system significance goes against the mentioned specific NO-agent drawbacks and against the current lack of suited NO-related therapy to specify and resolve given etiopathology [124,125]