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The gut-derived incretin hormone glucagon-like peptide 1 (GLP-1) is secreted upon meal ingestion and controls glucose metabolism by modulating pancreatic islet cell function, food intake and gastrointestinal motility, amongst other effects
GLP-1 RAs are designed to last much longer, from the time you take one dose until the time the next is due
The key was setting clear rules: when I hit 215, I restart immediately
Counting by indication: all 27 list obesity as an active indication
According to this scenario, obesity and hyperinsulinemia initiate a vicious metabolic cycle leading to deterioration of glucose tolerance and eventual development of T2DM
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