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Its makeup is altered so as to distinguish it from natural peptides

The resulting catastrophic energy deficit is a primary physiological driver of post-exertional malaise (PEM) or 'crashes,' where even minor, everyday activities trigger a disproportionate and prolonged exacerbation of profound fatigue, muscle weakness, and cognitive impairment

Exp Mol Med (2016) 48:e2244

GIP has decreased food intake and increased energy expenditure, resulting in weight reductions

acquired malignancy, pregnancy, OCP use, inflammatory disease, heparin-induced thrombocytopenia) Once a thrombus forms, it can propagate proximally (distal to proximal extension, increasing PE risk), embolize to the pulmonary arteries (PE see separate CDG), or undergo fibrinolysis (spontaneous resolution) or organization (becoming chronic/fibrotic)