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For example, Regeneron recently showed combining its antibody trevogrumab with semaglutide helped preserve lean mass while increasing fat mass loss

The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs

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These data also suggest that under conditions favoring fat mobilization and oxidation, hepatic fat is preferentially mobilized over fat from adipose tissue depots