By employing small interfering RNA (siRNA) to knock down CSF-1R expression, studies have demonstrated successful reprogramming of TAMs, shifting them from the M2 phenotype to the M1 phenotype (Li et al., 2020)
[DOI] [PubMed] [Google Scholar] 103.Lozic M., Stambolija V., Krezic I., Dugandzic A., Zivanovic-Posilovic G., Gojkovic S., Kovacevic J., Vrdoljak L., Mirkovic I., Kokot A., et al
Abstract Silent information regulator (SIRT) has distinctive enzymatic activities and physiological functions to control cell-cycle progression, gene expression, and DNA stability by targeting histone and non-histone proteins
TRMA is also referred to as thiamine metabolism dysfunction syndrome 1 (THMD1)
Based on these findings, the two labs collaborated to investigate whether aggressive melanomas use lactate consumption to survive the stress that cells experience during metastasis