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This approach appeals to patients whose genetic testing suggests stronger activation of both receptor pathways or those whose single-agent plateau reflects incomplete pathway engagement

GLP-1 medicines started with injectable GLP-1RAs, then moved to oral peptides, and now co-agonists

This makes it valuable not just for skin but for whole-body recovery and long-term health maintenance

Dela Cruz A, Kartha V, Tilston-Lunel A, Mi R, Reynolds TL, Mingueneau M, et al

In addition to weight loss, Wegovy is approved to lower the risk of serious heart problems like heart attacks and stroke in obese or overweight adults with heart disease