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If nausea or side effects are making you hesitant to go up, stay where you are and give your body more time to adjust first
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Meal composition also affects speed: eating large amounts of simple carbohydrates or high-fat foods before peak drug levels blunts appetite suppression compared to protein-forward meals
Br J Clin Pharmacol 52:137144 Bailey CJ, Wilcock C, Day C (1992) Effect of metformin on glucose metabolism in the splanchnic bed
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