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This effect may diminish over time with continued use and requires caution in patients with severe gastrointestinal disease or gastroparesis

I have found that patients who lose weight slowly do better in the long termit seems to give skin the ability to adapt to changes and shrink down to the new underlying shape. The nutritional point, in particular, may play an outsize role, says Rajesh Dhirmalani, DO, a gastroenterologist in New Jersey, and medical advisor to Replenza, a nutritional support brand for GLP-1 users

It, too, had a page describing the Grns study, in slightly more detail

An explosion in the use of the GLP-1s like Ozempic, Wegovy, Rybelsus, Mounjaro and Zepbound has subsequently resulted in an overabundance of used needles

Live bacteria actively colonize the gut and create the disruption necessary for microbiome change