Native, unmodified peptides are typically cleaved rapidly by serum dipeptidyl peptidase-4 (DPP-4), neutral endopeptidase, and aminopeptidases
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In clinical practice, it was also found that immune activation led to a rapid and significant upregulation of GLP-1R expression in naive CD4 + T cells enriched more than 40-fold from the human body (93)
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