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Some in vitro studies have shown that TNF may reduce melanocytestimulating hormone receptor binding activity, MC1R expression, or melanosomal protein gp87 expression, all of which promote melanogenesis

For these patients, we may recommend semaglutide

In the context of an acute inflammatory state, neutrophils are the initial immune cells that move into tissues, where they secrete chemokines to expedite the recruitment of monocytes into these tissues [130]

alternative dosing schedules or formulations (such as oral semaglutide or tirzepatide) may provide better tolerability