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Yes, vitamin C serum can help lighten dark spots and even out lip pigmentation due to its brightening properties

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Given that one of the severely damaged regions following TBI is the cerebellar circuit, PQQ could stimulates neurite regeneration in a wound recovery model using cultured cerebellar granular neurons (CGNs) (Shanan et al., 2019)

With meals: You can take it on an empty stomach, so long as it doesnt lead to GI discomfort

Over-the-counter stool softeners like docusate sodium (100mg twice daily) or polyethylene glycol can provide relief within 12-72 hours when dietary changes aren't sufficient