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This metabolic shift produces fewer direct diuretic effects than glycogen depletion, so urination frequency often normalises after the initial phase

Theyre crucial for feeling satisfied and holding onto muscle

Here is how experienced researchers track their progress

However, they are not FDA approved to treat hyperphagia, and most of the newer GLP-1s (Ozempic/semaglutide, Mounjaro/tirzepatide, and others) have not been studied in individuals with PWS

260,261 These changes amplify inflammation triggered by environmental insults such as cigarette smoke, while accelerated cellular aging (e.g., telomere shortening in alveolar cells) further drives oxidative stress and apoptosis