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7d), the cysteine part of CME forms hydrogen bonds with D180, E184, and Q359

Avoid excessive heat and protect from freezing

However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)

In mice, supplementation with auraptene (P45-60) and umbelliprennin in males (for 7 days between P51-60) [62] prevented POS-induced anxiety-like behavior in OFT and EPM at two months of age [63] and in the EPM immediately after treatment [62]