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The concentration of MOTS-c influenced the expressions of these genes, and knockdown of TGF- or SMAD7 partially reversed the increase in collagen expression, indicating the involvement of the TGF-/SMAD pathway

Following this strategy, different metabolic pathways for carbohydrate, lipid, and protein metabolism could be influenced simultaneously

However, because carnitine transport into the muscles is heavily mediated by insulin, some functional medicine practitioners recommend taking it alongside a small amount of complex carbohydrates to trigger a mild insulin response, which actively drives the carnitine into the muscle cells

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doi: 10.1046/j.1467-789x.2000.00019.x 81 MatsuzawaYSugiyamaSSugamuraKSumidaHKurokawaHFujisueKet al