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doi: 10.1016/0304-4165(85)90182-5 27 CozzaGRossettoMBosello-TravainVMaiorinoMRoveriAToppoSet al

Sci Rep (2017) 7(1):14076

A practical way to read the two cadences together: the weekly 5-on/2-off rhythm is a fine-grained pause aimed at short-term receptor sensitivity, while the 812-on / 4-off macro-cycle is the coarse-grained pause aimed at the whole axis

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"Given the scale of unmet need, we welcome options that help improve access for patients." But he added, "I'm not saying that I'm not concerned about market share