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The most commonly reported side effect among those who took orforglipron included mild to moderate gastrointestinal issues, such as constipation, diarrhea, indigestion, nausea, and vomiting

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For adult-only formulations, tirzepatide (Zepbound) is currently approved for individuals 18 years and older with a BMI of 30 kg/m or greater, or 27 kg/m or greater with at least one weight-related comorbidity such as hypertension or type 2 diabetes

K-means clustering algorithms: A comprehensive review, variants analysis, and advances in the era of big data