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Abnormal renal retention of sodium leads to concomitant water retention, expansion of plasma volume, and subsequently edema and ascites

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From Week 6 onward, the p-values showed no significant difference between groups

Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (Vinciguerra et al., 2020), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (Vinciguerra et al., 2020