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Reduced food and fluid intake on GLP-1 medications can cause electrolyte imbalances, manifesting as muscle cramps, headaches, or irregular heartbeat

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The M1 phenotype is often associated with disease, resulting in production and secretion of pro-inflammatory cytokines (i.e., tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation

Spatial memory is the part of the memory that is responsible for recording the environment and one's spatial awareness to it

Adaptive phenotype After several weeks: increased mitochondrial number and density per fiber, shift from type IIa/IIx toward type I oxidative fibers, increased muscle capillarization, improved maximum aerobic capacity (VO2max), increased endurance