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Inflammatory mediators can cross the bloodbrain barrier, activating the microglia and leading to the release of neurotoxic factors with adverse effects on dopaminergic neurons [21]

Consequently, PCOS women were treated with the daily administration of 220 mg zinc sulfate (containing 50 mg zinc) for 8 weeks and found that this regimen resulted in the improvement of their metabolic profiles (142)

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50,51 Recent metabonomics retrospective studies had shown that increased plasma levels of BCAAs are associated with an increased risk of pancreatic cancer, which was validated in a genetically engineered mouse model of pancreatic ductal adenocarcinoma (PDAC)