The recommended approach is to establish one intervention first, allow four to eight weeks for adaptation, and then gradually introduce the second
Surgical planning Researchers who may need surgery should understand that GLP-1 agonists slow gastric emptying, which can increase aspiration risk during anesthesia
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GLP-1R activation exerted antifibrotic effects by disrupting the interaction between the NLRP3 inflammasome and PFKFB3-driven glycolysis, and subsequently inhibiting lactate-mediated histone lactylation to reduce the expression of profibrotic genes in activated lung fibroblasts (Fig