Nasal spray delivery provides relatively direct CNS access through the olfactory and trigeminal nerve pathways
Derivatives thereof A61K38/06Tripeptides A61K38/063Glutathione Definitions SAG S-acetyl-glutathione Glutathione a tri-peptide molecule consisting of the amino acids L-glycine, L-csyteine, and L-glutamic acid (also known as L-glutamate), is the major intracellular antioxidant in humans
However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis
It belongs to a class of drugs known as dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists
March 6, 2023