Published large human clinical-trial data is not available, so a regulator-grade answer to that question does not exist
More recent meta-analyses of prospective cohort studies in older adults have not found a relationship between blood cobalamin concentration or dietary vitamin B 12 intake and cognitive decline or dementia (80, 81)
Vitamin D3 deficiencies can directly influence our immune response and has been implicated as being a major factor of at least 17 varieties of cancer, heart disease, stroke, depression, chronic pain, and much more
One study found that even up to 2,000 micrograms a day of methylcobalamin wasnt enough to correct vitamin B12 deficiency in one of three vegans tested

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