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Participants received once-weekly injections of retatrutide at either the 9mg or 12mg dose, or a placebo, over 68 weeks

Intravenous (IV) administration is considered the most effective delivery method for both NAD+ and glutathione

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Higher doses consistently showed significant reductions in liver enzymes (AST and ALT), hepatic steatosis, and inflammation, although the effect on fibrosis was limited

Late-afternoon dosing (4-6pm) is optimal for most patients because dinner is typically the highest-calorie meal and circadian amylin sensitivity peaks in this window