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The APP Dutch mouse model, carrying the E693Q mutation (APP751) under the murine Thy1 promoter, exhibited no neurofibrillary tangles (NFTs) or amyloid plaques

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Preclinical and cell culture research has examined exogenous glutathione for its capacity to replenish intracellular GSH pools under oxidative stress conditions, modulating Nrf2/ARE pathway activity and mitochondrial redox balance