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Centrally, they manage appetite and cravings by modulating the reward circuitry in the brain, while peripherally, they correct systemic metabolism and reduce hepatic fat accumulation (Jones and Brierley, 2025
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Subgroup analyses showed no significant risk of pancreatitis among patients who had concomitant background medications and patients who did not, which indicates that background medications did not confound the relationship between GLP1 RA usage and pancreatitis
Proteins 17 , 31843198 (2025)
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