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Without addressing underlying hormonal signals, fat loss and muscle preservation may not happen as efficiently as you expect

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Black R.E., Allen L.H., Bhutta Z.A., Caulfield L.E., De Onis M., Ezzati M., Mathers C., Rivera J

However, persistent side effects may reduce treatment adherence, slowing progress

These changes enhance the activity of the renin-angiotensin system (RAAS), contributing to vasoconstriction, sodium retention, and heightened blood pressure, thereby exacerbating the risk of hypertension [460]

Exercise caution if you have liver disease, gout, or existing electrolyte imbalances, as spironolactone could worsen these conditions