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To examine molecular mechanisms of this phenomenon, exendin (939)specific inhibitor of GLP-1 receptor, Rp-cAMPthe cAMP inhibitor, PI3 K inhibitor LY294002 or p44/42 mitogen-activated protein kinase inhibitor UO126, were given concomitantly with GLP-1 + VP infusion

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0.9% in controls) ( Table 1 )

In our experiment, rats were reared in the hypobaric oxygen chamber for 28 days to simulate a high-altitude environment