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doi: 10.3389/fphar.2022.850813 Received 19 January 2022 Accepted 25 February 2022 Published 18 March 2022 Volume 13 - 2022 Edited by Gokhan Zengin, Selcuk University, Turkey Reviewed by Ulrike Lindequist, University of Greifswald, Germany Emanuel Vamanu, University of Agricultural Sciences and Veterinary Medicine, Romania Updates Copyright 2022 Fu and Shen

It is important to highlight the variability of clinical data

Who benefits most B12 shots make the biggest difference for people who are genuinely low, including vegans and vegetarians, older adults, and people with conditions like Crohn's disease that limit absorption

4.4 Pharmacokinetics and bioavailability As described above, BBR has a low bioavailability and poor oral absorption, at less than 1% across various in vivo and in vitro studies [60]