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Epigenetic factors such as the histone demethylase KDM6B, the transcription co-factor and chromatin remodeler Zmiz1, and the MSNP1AS long non-coding RNA (lncRNA) have been reported to modulate mTOR activity

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Available data on pediatric populations show controversial results, ranging from the absence of relevant changes in anti-seizure drugs' blood concentration (15) to subtle changes in topiramate, levetiracetam, phenobarbital, and carbamazepine and possibly significant changes in valproate concentration under the influence of KDT (16)

Hasan AA, Kalinina E, Tatarskiy V, Shtil A