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DAN can impact various organ systems, including the cardiovascular, gastrointestinal, genitourinary, and sudomotor systems, leading to significant morbidity and mortality among diabetes patients

Notably, the supplementation of astaxanthin, compared to thermal stress alone, inhibited the expression of inflammatory factors and apoptosis-related genes, including TLR2 , IL8 , EIF4E , IL2RB , CASP3 , and CASP9

Further research is needed to assess safety, dosage, and potential side effects

Peptides are short chains of amino acids that act as biological messengers in the body

This was accompanied by a reduced distribution of these proteins at the plasma membrane and an increase in IEC permeability