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Side effects and challenges during treatment Dramatic transformations omit the nausea , vomiting, constipation, fatigue, and other side effects many people experience during treatment

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US Patent US5538945A provides intellectual history but not clinical evidence

Both groups lost weight, but those with prior treatment lost less

However, conventional meta-analyses are typically limited to pairwise comparisons and are unable to simultaneously evaluate multiple GLP-1RAs, which restricts their clinical applicability